4R9S

Mycobacterium tuberculosis InhA bound to NITD-916

Summary for 4R9S

• Entry DOI: 10.2210/pdb4r9s/pdb
• Related: 4R9R
• Descriptor: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, ... (4 entities in total)
• Functional Keywords: enoyl acyl carrier protein reductase, oxidoreductase
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 4
• Total formula weight: 119247.60

Authors

Noble, C.G. (deposition date: 2014-09-07, release date: 2015-01-21, Last modification date: 2023-11-08)

• Primary citation: Manjunatha, U.H.,Rao, S.P.S.,Kondreddi, R.R.,Noble, C.G.,Camacho, L.R.,Tan, B.H.,Ng, S.H.,Ng, P.S.,Ma, N.L.,Lakshminarayana, S.B.,Herve, M.,Barnes, S.W.,Yu, W.,Kuhen, K.,Blasco, F.,Beer, D.,Walker, J.R.,Tonge, P.J.,Glynne, R.,Smith, P.W.,Diagana, T.T.; Direct inhibitors of InhA are active against Mycobacterium tuberculosis; Sci Transl Med, 7:269ra3-269ra3, 2015; PubMed: 25568071; DOI: 10.1126/scitranslmed.3010597

Experimental method

X-RAY DIFFRACTION (3.2 Å)