4R9S
Mycobacterium tuberculosis InhA bound to NITD-916
Summary for 4R9S
Entry DOI | 10.2210/pdb4r9s/pdb |
Related | 4R9R |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, ... (4 entities in total) |
Functional Keywords | enoyl acyl carrier protein reductase, oxidoreductase |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 4 |
Total formula weight | 119247.60 |
Authors | Noble, C.G. (deposition date: 2014-09-07, release date: 2015-01-21, Last modification date: 2023-11-08) |
Primary citation | Manjunatha, U.H.,Rao, S.P.S.,Kondreddi, R.R.,Noble, C.G.,Camacho, L.R.,Tan, B.H.,Ng, S.H.,Ng, P.S.,Ma, N.L.,Lakshminarayana, S.B.,Herve, M.,Barnes, S.W.,Yu, W.,Kuhen, K.,Blasco, F.,Beer, D.,Walker, J.R.,Tonge, P.J.,Glynne, R.,Smith, P.W.,Diagana, T.T. Direct inhibitors of InhA are active against Mycobacterium tuberculosis Sci Transl Med, 7:269ra3-269ra3, 2015 Cited by PubMed: 25568071DOI: 10.1126/scitranslmed.3010597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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