4R5P
Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor
4R5P の概要
エントリーDOI | 10.2210/pdb4r5p/pdb |
関連するPDBエントリー | 3V4I |
関連するBIRD辞書のPRD_ID | PRD_900003 |
分子名称 | HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 5'-D(*TP*GP*GP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3', ... (9 entities in total) |
機能のキーワード | zidovudine, rt-dna complex, aids, dna-directed dna polymerase, rn lipoprotein, hiv, metal-binding, alpha-cnp, ribonuclease h, rnase h, a-cnp, multifunctional enzyme, nucleotidyltransferase, rna-directed polymerase, transferase, hydrolase-dna-inhibitor complex, hydrolase/dna/inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 (HIV-1) 詳細 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
タンパク質・核酸の鎖数 | 8 |
化学式量合計 | 259540.17 |
構造登録者 | |
主引用文献 | Balzarini, J.,Das, K.,Bernatchez, J.A.,Martinez, S.E.,Ngure, M.,Keane, S.,Ford, A.,Maguire, N.,Mullins, N.,John, J.,Kim, Y.,Dehaen, W.,Vande Voorde, J.,Liekens, S.,Naesens, L.,Gotte, M.,Maguire, A.R.,Arnold, E. Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc.Natl.Acad.Sci.USA, 112:3475-3480, 2015 Cited by PubMed: 25733891DOI: 10.1073/pnas.1420233112 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.894 Å) |
構造検証レポート
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