4R4Q

Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid

Summary for 4R4Q

Related4R4C 4R4I 4R4O 4R4T
DescriptorReplication protein A 70 kDa DNA-binding subunit, 5-[4-({acetyl[4-(5-carboxyfuran-2-yl)benzyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total)
Functional Keywordsob-fold, protein-protein interaction, protein binding
Biological sourceHomo sapiens (human)
Cellular locationNucleus  P27694
Total number of polymer chains1
Total molecular weight14102.17
Authors
Feldkamp, M.D.,Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Frank, A.O.,Vangamudi, B.,Sousa-Fagundes, E.M.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2014-08-19, release date: 2014-11-19, Last modification date: 2015-03-11)
Primary citation
Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.
Diphenylpyrazoles as replication protein a inhibitors.
ACS Med Chem Lett, 6:140-145, 2015
PubMed: 25699140 (PDB entries with the same primary citation)
DOI: 10.1021/ml5003629
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.35 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19060.8%05.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4r4q
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Molmil generated image of 4r4q
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Molmil generated image of 4r4q
rotated about y axis by 90°