4R4Q
Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Summary for 4R4Q
Entry DOI | 10.2210/pdb4r4q/pdb |
Related | 4R4C 4R4I 4R4O 4R4T |
Descriptor | Replication protein A 70 kDa DNA-binding subunit, 5-[4-({acetyl[4-(5-carboxyfuran-2-yl)benzyl]amino}methyl)phenyl]-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid (3 entities in total) |
Functional Keywords | ob-fold, protein-protein interaction, protein binding |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P27694 |
Total number of polymer chains | 1 |
Total formula weight | 14102.16 |
Authors | Feldkamp, M.D.,Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Frank, A.O.,Vangamudi, B.,Sousa-Fagundes, E.M.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (deposition date: 2014-08-19, release date: 2014-11-19, Last modification date: 2024-02-28) |
Primary citation | Waterson, A.G.,Kennedy, J.P.,Patrone, J.D.,Pelz, N.F.,Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W. Diphenylpyrazoles as replication protein a inhibitors. ACS Med Chem Lett, 6:140-145, 2015 Cited by PubMed: 25699140DOI: 10.1021/ml5003629 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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