4R3Q

Crystal structure of SYCE3

4R3Q の概要

• エントリーDOI: 10.2210/pdb4r3q/pdb
• 分子名称: Synaptonemal complex central element protein 3 (2 entities in total)
• 機能のキーワード: coiled-coil, synaptonemal complex, cell cycle
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Nucleus : B5KM66
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 20960.03

構造登録者

Lu, J.,Feng, J.,Zhou, W.,Yang, X.,Shen, Y. (登録日: 2014-08-17, 公開日: 2014-11-26, 最終更新日: 2024-03-20)

主引用文献

Lu, J.,Gu, Y.,Feng, J.,Zhou, W.,Yang, X.,Shen, Y.
Structural insight into the central element assembly of the synaptonemal complex
Sci Rep, 4:7059-7059, 2014

PubMed Abstract: The key step in meiosis is synaptonemal complex formation, which mediates homologous chromosome alignment and synapsis. False pairing between homologous chromosomes produces infertility. Here, we present a crystal structure of the mouse meiosis-specific protein SYCE3, which is a component of the synaptonemal complex central element. Our studies show that functional SYCE3 most likely forms a dimer or higher order oligomer in cells. Furthermore, we demonstrate that the SYCE3 N-helix interacts with the SYCE1 C-helix, which is another central element component. Our results suggest that helical packing may mediate intra- or inter-association of each central element protein component, thereby playing an essential role in forming the synaptonemal complex central elements.

PubMed: 25394919
DOI: 10.1038/srep07059

実験手法

X-RAY DIFFRACTION (1.901 Å)