4R3M
Crystal structure of Human Hsp90 with JR9
Summary for 4R3M
Entry DOI | 10.2210/pdb4r3m/pdb |
Descriptor | Heat shock protein HSP 90-alpha, N~3~-benzyl-2-[(6-bromo-1,3-benzodioxol-5-yl)methyl]imidazo[1,2-a]pyrazine-3,8-diamine (3 entities in total) |
Functional Keywords | chaperone/chaperone inhibitor, chaperone-chaperone inhibitor complex |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 23844.82 |
Authors | |
Primary citation | Ren, J.,Yang, M.,Liu, H.,Cao, D.,Chen, D.,Li, J.,Tang, L.,He, J.,Chen, Y.L.,Geng, M.,Xiong, B.,Shen, J. Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke-Blackburn-Bienayme reaction and their Hsp90 inhibitory activity. Org.Biomol.Chem., 13:1531-1535, 2015 Cited by PubMed: 25490978DOI: 10.1039/c4ob01865f PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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