4QYY
Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State
Summary for 4QYY
Entry DOI | 10.2210/pdb4qyy/pdb |
Descriptor | Mitogen-activated protein kinase 1, (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P63086 |
Total number of polymer chains | 1 |
Total formula weight | 43003.67 |
Authors | Deng, Y.,Shipps, G.W.,Cooper, A.,English, J.M.,Annis, D.A.,Carr, D.,Nan, Y.,Wang, T.,Zhu, Y.H.,Chuang, C.,Dayananth, P.,Hruza, A.W.,Xiao, L.,Jin, W.,Kirschmeier, P.,Windsor, W.T.,Samatar, A.A. (deposition date: 2014-07-26, release date: 2014-11-12, Last modification date: 2023-09-20) |
Primary citation | Deng, Y.,Shipps, G.W.,Cooper, A.,English, J.M.,Annis, D.A.,Carr, D.,Nan, Y.,Wang, T.,Zhu, H.Y.,Chuang, C.C.,Dayananth, P.,Hruza, A.W.,Xiao, L.,Jin, W.,Kirschmeier, P.,Windsor, W.T.,Samatar, A.A. Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57:8817-8826, 2014 Cited by PubMed: 25313996DOI: 10.1021/jm500847m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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