4QYY
Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State
4QYY の概要
エントリーDOI | 10.2210/pdb4qyy/pdb |
分子名称 | Mitogen-activated protein kinase 1, (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, SULFATE ION, ... (4 entities in total) |
機能のキーワード | transferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Rattus norvegicus (brown rat,rat,rats) |
細胞内の位置 | Cytoplasm, cytoskeleton, spindle : P63086 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 43003.67 |
構造登録者 | Deng, Y.,Shipps, G.W.,Cooper, A.,English, J.M.,Annis, D.A.,Carr, D.,Nan, Y.,Wang, T.,Zhu, Y.H.,Chuang, C.,Dayananth, P.,Hruza, A.W.,Xiao, L.,Jin, W.,Kirschmeier, P.,Windsor, W.T.,Samatar, A.A. (登録日: 2014-07-26, 公開日: 2014-11-12, 最終更新日: 2023-09-20) |
主引用文献 | Deng, Y.,Shipps, G.W.,Cooper, A.,English, J.M.,Annis, D.A.,Carr, D.,Nan, Y.,Wang, T.,Zhu, H.Y.,Chuang, C.C.,Dayananth, P.,Hruza, A.W.,Xiao, L.,Jin, W.,Kirschmeier, P.,Windsor, W.T.,Samatar, A.A. Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57:8817-8826, 2014 Cited by PubMed: 25313996DOI: 10.1021/jm500847m 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.65 Å) |
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