4QYA

Crystal structure of human transthyretin variant V30M in complex with luteolin

4QYA の概要

• エントリーDOI: 10.2210/pdb4qya/pdb
• 分子名称: Transthyretin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: amyloid fibrils, transport protein, vitamin a, retinol-binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P02766
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28214.31

構造登録者

Begum, A.,Olofsson, A.,Sauer-Eriksson, A.E. (登録日: 2014-07-24, 公開日: 2015-06-03, 最終更新日: 2024-02-28)

• 主引用文献: Iakovleva, I.,Begum, A.,Pokrzywa, M.,Walfridsson, M.,Sauer-Eriksson, A.E.,Olofsson, A.; The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response.; Plos One, 10:e0128222-e0128222, 2015; PubMed: 26020516; DOI: 10.1371/journal.pone.0128222

実験手法

X-RAY DIFFRACTION (1.7 Å)