4QY2

Structure of H10 from human-infecting H10N8 virus in complex with human receptor analog

4QY2 の概要

• エントリーDOI: 10.2210/pdb4qy2/pdb
• 関連するPDBエントリー: 4QY0 4QY1
• 分子名称: hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid, ... (5 entities in total)
• 機能のキーワード: receptor binding, memebrane fusion, viral protein
• 由来する生物種: Influenza A virus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 331872.90

構造登録者

Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F. (登録日: 2014-07-23, 公開日: 2015-01-28, 最終更新日: 2024-10-16)

主引用文献

Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F.
Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
Nat Commun, 6:5600-5600, 2015

PubMed Abstract: Since December 2013, at least three cases of human infections with H10N8 avian influenza virus have been reported in China, two of them being fatal. To investigate the epidemic potential of H10N8 viruses, we examined the receptor binding property of the first human isolate, A/Jiangxi-Donghu/346/2013 (JD-H10N8), and determined the structures of its haemagglutinin (HA) in complex with both avian and human receptor analogues. Our results suggest that JD-H10N8 preferentially binds the avian receptor and that residue R137-localized within the receptor-binding site of HA-plays a key role in this preferential binding. Compared with the H7N9 avian influenza viruses, JD-H10N8 did not exhibit the enhanced binding to human receptors observed with the prevalent H7N9 virus isolate Anhui-1, but resembled the receptor binding activity of the early-outbreak H7N9 isolate (Shanghai-1). We conclude that the H10N8 virus is a typical avian influenza virus.

PubMed: 25574798
DOI: 10.1038/ncomms6600

実験手法

X-RAY DIFFRACTION (2.399 Å)