4QY1

Structure of H10 from human-infecting H10N8 in complex with avian receptor

Summary for 4QY1

• Entry DOI: 10.2210/pdb4qy1/pdb
• Related: 4QY0 4QY2
• Related PRD ID: PRD_900067
• Descriptor: hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: receptor binding, memebrane fusion, viral protein
• Biological source: Influenza A virus; More
• Total number of polymer chains: 24
• Total formula weight: 666471.28

Authors

Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F. (deposition date: 2014-07-23, release date: 2015-01-28, Last modification date: 2024-10-30)

Primary citation

Wang, M.,Zhang, W.,Qi, J.,Wang, F.,Zhou, J.,Bi, Y.,Wu, Y.,Sun, H.,Liu, J.,Huang, C.,Li, X.,Yan, J.,Shu, Y.,Shi, Y.,Gao, G.F.
Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus
Nat Commun, 6:5600-5600, 2015

PubMed Abstract: Since December 2013, at least three cases of human infections with H10N8 avian influenza virus have been reported in China, two of them being fatal. To investigate the epidemic potential of H10N8 viruses, we examined the receptor binding property of the first human isolate, A/Jiangxi-Donghu/346/2013 (JD-H10N8), and determined the structures of its haemagglutinin (HA) in complex with both avian and human receptor analogues. Our results suggest that JD-H10N8 preferentially binds the avian receptor and that residue R137-localized within the receptor-binding site of HA-plays a key role in this preferential binding. Compared with the H7N9 avian influenza viruses, JD-H10N8 did not exhibit the enhanced binding to human receptors observed with the prevalent H7N9 virus isolate Anhui-1, but resembled the receptor binding activity of the early-outbreak H7N9 isolate (Shanghai-1). We conclude that the H10N8 virus is a typical avian influenza virus.

PubMed: 25574798
DOI: 10.1038/ncomms6600

Experimental method

X-RAY DIFFRACTION (2.594 Å)