4QXX

Structure of the amyloid forming peptide GNLVS (residues 26-30) from the eosinophil major basic protein (EMBP)

4QXX の概要

• エントリーDOI: 10.2210/pdb4qxx/pdb
• 分子名称: Bone marrow proteoglycan (2 entities in total)
• 機能のキーワード: amyloid-like protofibril, protein fibril
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Bone marrow proteoglycan: Secreted. Eosinophil granule major basic protein: Cytoplasmic vesicle, secretory vesicle: P13727
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 488.54

構造登録者

Soriaga, A.B.,Soragni, A.,Sawaya, M.R.,Eisenberg, D. (登録日: 2014-07-22, 公開日: 2015-03-18, 最終更新日: 2024-02-28)

• 主引用文献: Soragni, A.,Yousefi, S.,Stoeckle, C.,Soriaga, A.B.,Sawaya, M.R.,Kozlowski, E.,Schmid, I.,Radonjic-Hoesli, S.,Boutet, S.,Williams, G.J.,Messerschmidt, M.,Seibert, M.M.,Cascio, D.,Zatsepin, N.A.,Burghammer, M.,Riekel, C.,Colletier, J.P.,Riek, R.,Eisenberg, D.S.,Simon, H.U.; Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation.; Mol.Cell, 57:1011-1021, 2015; PubMed: 25728769; DOI: 10.1016/j.molcel.2015.01.026

実験手法

X-RAY DIFFRACTION (1.445 Å)