4QXK

Joint X-ray/neutron structure of PKGIbeta in complex with cGMP

4QXK の概要

• エントリーDOI: 10.2210/pdb4qxk/pdb
• 分子名称: cGMP-dependent protein kinase 1, CYCLIC GUANOSINE MONOPHOSPHATE, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: cyclic gmp (cgmp), type i cgmp dependent protein kinase (pkg i), cyclic nucleotide selectivity, serine/threonine protein kinase, signal transduction, second messengers, hydrogen bonding, solvent accessibility, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17314.01

構造登録者

Kim, C.,Gerlits, O.,Kovalevsky, A.,Huang, G.Y. (登録日: 2014-07-21, 公開日: 2014-11-12, 最終更新日: 2024-02-28)

• 主引用文献: Huang, G.Y.,Gerlits, O.O.,Blakeley, M.P.,Sankaran, B.,Kovalevsky, A.Y.,Kim, C.; Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design.; Biochemistry, 53:6725-6727, 2014; PubMed: 25271401; DOI: 10.1021/bi501012v

実験手法

NEUTRON DIFFRACTION (2.2 Å)
X-RAY DIFFRACTION