4QQ6
Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule
Summary for 4QQ6
Entry DOI | 10.2210/pdb4qq6/pdb |
Descriptor | Survival motor neuron protein, UNKNOWN ATOM OR ION, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, ... (4 entities in total) |
Functional Keywords | structural genomics, structural genomics consortium, sgc, rna binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q16637 |
Total number of polymer chains | 1 |
Total formula weight | 7597.57 |
Authors | Liu, Y.,Tempel, W.,Iqbal, A.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2014-06-26, release date: 2014-08-06, Last modification date: 2023-09-20) |
Primary citation | Liu, Y.,Iqbal, A.,Li, W.,Ni, Z.,Wang, Y.,Ramprasad, J.,Abraham, K.J.,Zhang, M.,Zhao, D.Y.,Qin, S.,Loppnau, P.,Jiang, H.,Guo, X.,Brown, P.J.,Zhen, X.,Xu, G.,Mekhail, K.,Ji, X.,Bedford, M.T.,Greenblatt, J.F.,Min, J. A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun, 13:5453-5453, 2022 Cited by PubMed: 36114190DOI: 10.1038/s41467-022-33229-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report