4QQ6

Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule

4QQ6 の概要

• エントリーDOI: 10.2210/pdb4qq6/pdb
• 分子名称: Survival motor neuron protein, UNKNOWN ATOM OR ION, 4-methyl-2,3,4,5,6,7-hexahydrodicyclopenta[b,e]pyridin-8(1H)-imine, ... (4 entities in total)
• 機能のキーワード: structural genomics, structural genomics consortium, sgc, rna binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q16637
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7597.57

構造登録者

Liu, Y.,Tempel, W.,Iqbal, A.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Min, J.,Structural Genomics Consortium (SGC) (登録日: 2014-06-26, 公開日: 2014-08-06, 最終更新日: 2023-09-20)

• 主引用文献: Liu, Y.,Iqbal, A.,Li, W.,Ni, Z.,Wang, Y.,Ramprasad, J.,Abraham, K.J.,Zhang, M.,Zhao, D.Y.,Qin, S.,Loppnau, P.,Jiang, H.,Guo, X.,Brown, P.J.,Zhen, X.,Xu, G.,Mekhail, K.,Ji, X.,Bedford, M.T.,Greenblatt, J.F.,Min, J.; A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.; Nat Commun, 13:5453-5453, 2022; PubMed: 36114190; DOI: 10.1038/s41467-022-33229-5

実験手法

X-RAY DIFFRACTION (1.75 Å)