4QO2

Crystal structure of rhomboid intramembrane protease GlpG in complex with peptide derived inhibitor Ac-IATA-cmk

4QO2 の概要

• エントリーDOI: 10.2210/pdb4qo2/pdb
• 関連するPDBエントリー: 4QNZ 4QO0
• 関連するBIRD辞書のPRD_ID: PRD_001252
• 分子名称: Rhomboid protease GlpG, 6-AMINO-2-METHYL-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE, nonyl beta-D-glucopyranoside, ... (5 entities in total)
• 機能のキーワード: alpha-helical, rhomboid intramembrane protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cell inner membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity): U6NA71
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27495.84

構造登録者

Zoll, S.,Strisovsky, K. (登録日: 2014-06-19, 公開日: 2014-09-24, 最終更新日: 2023-09-20)

• 主引用文献: Zoll, S.,Stanchev, S.,Began, J.,Skerle, J.,Lepsik, M.,Peclinovska, L.,Majer, P.,Strisovsky, K.; Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate-peptide complex structures.; Embo J., 33:2408-2421, 2014; PubMed: 25216680; DOI: 10.15252/embj.201489367

実験手法

X-RAY DIFFRACTION (2.1 Å)