4QIA
Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine
Summary for 4QIA
Entry DOI | 10.2210/pdb4qia/pdb |
Descriptor | Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION (3 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, inhibitor:41371, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 2 |
Total formula weight | 229972.70 |
Authors | Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2014-05-30, release date: 2015-05-13, Last modification date: 2024-02-28) |
Primary citation | Charton, J.,Gauriot, M.,Totobenazara, J.,Hennuyer, N.,Dumont, J.,Bosc, D.,Marechal, X.,Elbakali, J.,Herledan, A.,Wen, X.,Ronco, C.,Gras-Masse, H.,Heninot, A.,Pottiez, V.,Landry, V.,Staels, B.,Liang, W.G.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R. Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90:547-567, 2015 Cited by PubMed: 25489670DOI: 10.1016/j.ejmech.2014.12.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.202 Å) |
Structure validation
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