4QIA

Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine

Summary for 4QIA

• Entry DOI: 10.2210/pdb4qia/pdb
• Descriptor: Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION (3 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, inhibitor:41371, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P14735
• Total number of polymer chains: 2
• Total formula weight: 229972.70

Authors

Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2014-05-30, release date: 2015-05-13, Last modification date: 2024-02-28)

• Primary citation: Charton, J.,Gauriot, M.,Totobenazara, J.,Hennuyer, N.,Dumont, J.,Bosc, D.,Marechal, X.,Elbakali, J.,Herledan, A.,Wen, X.,Ronco, C.,Gras-Masse, H.,Heninot, A.,Pottiez, V.,Landry, V.,Staels, B.,Liang, W.G.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R.; Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.; Eur.J.Med.Chem., 90:547-567, 2015; PubMed: 25489670; DOI: 10.1016/j.ejmech.2014.12.005

Experimental method

X-RAY DIFFRACTION (3.202 Å)