4QIA

Crystal structure of human insulin degrading enzyme (ide) in complex with inhibitor N-benzyl-N-(carboxymethyl)glycyl-L-histidine

4QIA の概要

• エントリーDOI: 10.2210/pdb4qia/pdb
• 分子名称: Insulin-degrading enzyme, N-benzyl-N-(carboxymethyl)glycyl-L-histidine, ZINC ION (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, inhibitor:41371, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14735
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 229972.70

構造登録者

Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (登録日: 2014-05-30, 公開日: 2015-05-13, 最終更新日: 2024-02-28)

• 主引用文献: Charton, J.,Gauriot, M.,Totobenazara, J.,Hennuyer, N.,Dumont, J.,Bosc, D.,Marechal, X.,Elbakali, J.,Herledan, A.,Wen, X.,Ronco, C.,Gras-Masse, H.,Heninot, A.,Pottiez, V.,Landry, V.,Staels, B.,Liang, W.G.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R.; Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.; Eur.J.Med.Chem., 90:547-567, 2015; PubMed: 25489670; DOI: 10.1016/j.ejmech.2014.12.005

実験手法

X-RAY DIFFRACTION (3.202 Å)