4QH6

Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE

4QH6 の概要

• エントリーDOI: 10.2210/pdb4qh6/pdb
• 分子名称: Cruzipain, N-(2-aminoethyl)-Nalpha-benzoyl-L-phenylalaninamide (2 entities in total)
• 機能のキーワード: thiol protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 113887.04

構造登録者

Fernandes, W.B.,Montanari, C.A.,McKerrow, J.H. (登録日: 2014-05-27, 公開日: 2015-08-05, 最終更新日: 2023-09-20)

• 主引用文献: Avelar, L.A.,Camilo, C.D.,de Albuquerque, S.,Fernandes, W.B.,Goncalez, C.,Kenny, P.W.,Leitao, A.,McKerrow, J.H.,Montanari, C.A.,Orozco, E.V.,Ribeiro, J.F.,Rocha, J.R.,Rosini, F.,Saidel, M.E.; Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors.; Plos Negl Trop Dis, 9:e0003916-e0003916, 2015; PubMed: 26173110; DOI: 10.1371/journal.pntd.0003916

実験手法

X-RAY DIFFRACTION (3.13 Å)