4QC6

Crystal structure of aminoglycoside 6'-acetyltransferase-Ie

4QC6 の概要

• エントリーDOI: 10.2210/pdb4qc6/pdb
• 分子名称: Bifunctional AAC/APH, KANAMYCIN A, (3R,5S,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3,5-diphosphaheptadecane-17-sulfinic acid 3,5-dioxide (non-preferred name), ... (5 entities in total)
• 機能のキーワード: antibiotic resistance, gnat family, acetyltransferase, acetylcoenzyme-a, aminoglycoside, transferase, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Staphylococcus warneri
• 細胞内の位置: Cytoplasm : Q7ATH7
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46269.62

構造登録者

Smith, C.A.,Toth, M.,Weiss, T.M.,Frase, H.,Vakulenko, S.B. (登録日: 2014-05-09, 公開日: 2014-10-22, 最終更新日: 2024-02-28)

• 主引用文献: Smith, C.A.,Toth, M.,Weiss, T.M.,Frase, H.,Vakulenko, S.B.; Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia revealed by crystallographic and small-angle X-ray scattering analysis.; Acta Crystallogr.,Sect.D, 70:2754-2764, 2014; PubMed: 25286858; DOI: 10.1107/S1399004714017635

実験手法

X-RAY DIFFRACTION (1.3 Å)