4QAU

Crystal structure of F43Y mutant of sperm whale myoglobin

4QAU の概要

• エントリーDOI: 10.2210/pdb4qau/pdb
• 関連するPDBエントリー: 4IT8
• 分子名称: Myoglobin, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: alpha helix boundle, oxygen transport, f43y mutant
• 由来する生物種: Physeter catodon (Sperm whale)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17998.64

構造登録者

Lin, Y.,Tan, X.,Li, W. (登録日: 2014-05-06, 公開日: 2015-01-21, 最終更新日: 2023-11-08)

主引用文献

Yan, D.-J.,Li, W.,Xiang, Y.,Wen, G.-B.,Lin, Y.-W.,Tan, X.
A Novel Tyrosine-Heme C-O Covalent Linkage in F43Y Myoglobin: A New Post-translational Modification of Heme Proteins
Chembiochem, 16:47-50, 2015

PubMed Abstract: Heme post-translational modification plays a key role in tuning the structure and function of heme proteins. We herein report a novel tyrosine-heme covalent C−O bond in an artificially produced sperm whale myoglobin (Mb) mutant, F43Y Mb, which formed spontaneously in vivo between the Tyr43 hydroxy group and the heme 4-vinyl group. This highlights the diverse chemistry of heme post-translational modifications, and lays groundwork for further investigation of the structural and functional diversity of covalently-bound heme proteins.

PubMed: 25392956
DOI: 10.1002/cbic.201402504

実験手法

X-RAY DIFFRACTION (1.597 Å)