4Q6Y

Crystal structure of a chemoenzymatic glycoengineered disialylated Fc (di-sFc)

4Q6Y の概要

• エントリーDOI: 10.2210/pdb4q6y/pdb
• 関連するPDBエントリー: 4Q74 4Q7D
• 分子名称: Ig gamma-1 chain C region, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: immune system
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P01857
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 105806.37

構造登録者

Ahmed, A.A.,Giddens, J.,Pincetic, A.,Lomino, J.V.,Ravetch, J.V.,Wang, L.X.,Bjorkman, P.J. (登録日: 2014-04-23, 公開日: 2014-07-23, 最終更新日: 2023-09-20)

• 主引用文献: Ahmed, A.A.,Giddens, J.,Pincetic, A.,Lomino, J.V.,Ravetch, J.V.,Wang, L.X.,Bjorkman, P.J.; Structural characterization of anti-inflammatory immunoglobulin g fc proteins.; J.Mol.Biol., 426:3166-3179, 2014; PubMed: 25036289; DOI: 10.1016/j.jmb.2014.07.006

実験手法

X-RAY DIFFRACTION (3 Å)