4Q6U

Crystal structure of a putative uncharacterized protein from Mycobacterium tuberculosis

Summary for 4Q6U

• Entry DOI: 10.2210/pdb4q6u/pdb
• Descriptor: Uncharacterized protein, PENTAETHYLENE GLYCOL (3 entities in total)
• Functional Keywords: seattle structural genoics for infectious disease, mycobacterium tuberculosis, structural genomics, ssgcid, seattle structural genomics center for infectious disease, unknown function
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 78987.42

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2014-04-23, release date: 2014-06-18, Last modification date: 2024-11-27)

Primary citation

Abendroth, J.,Frando, A.,Phan, I.Q.,Staker, B.L.,Myler, P.J.,Edwards, T.E.,Grundner, C.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
Protein Sci., 27:568-572, 2018

PubMed Abstract: The genome of the human pathogen Mycobacterium tuberculosis (Mtb) encodes ∼4,400 proteins, but one third of them have unknown functions. We solved the crystal structure of Rv3651, a hypothetical protein with no discernible similarity to proteins with known function. Rv3651 has a three-domain architecture that combines one cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA (GAF) domain and two Per-ARNT-Sim (PAS) domains. GAF and PAS domains are sensor domains that are typically linked to signaling effector molecules. Unlike these sensor-effector proteins, Rv3651 is an unusual sensor domain-only protein with highly divergent sequence. The structure suggests that Rv3651 integrates multiple different signals and serves as a scaffold to facilitate signal transfer.

PubMed: 29119630
DOI: 10.1002/pro.3343

Experimental method

X-RAY DIFFRACTION (1.95 Å)