4Q6U

Crystal structure of a putative uncharacterized protein from Mycobacterium tuberculosis

4Q6U の概要

• エントリーDOI: 10.2210/pdb4q6u/pdb
• 分子名称: Uncharacterized protein, PENTAETHYLENE GLYCOL (3 entities in total)
• 機能のキーワード: seattle structural genoics for infectious disease, mycobacterium tuberculosis, structural genomics, ssgcid, seattle structural genomics center for infectious disease, unknown function
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78987.42

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2014-04-23, 公開日: 2014-06-18, 最終更新日: 2024-11-27)

主引用文献

Abendroth, J.,Frando, A.,Phan, I.Q.,Staker, B.L.,Myler, P.J.,Edwards, T.E.,Grundner, C.
Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein.
Protein Sci., 27:568-572, 2018

PubMed Abstract: The genome of the human pathogen Mycobacterium tuberculosis (Mtb) encodes ∼4,400 proteins, but one third of them have unknown functions. We solved the crystal structure of Rv3651, a hypothetical protein with no discernible similarity to proteins with known function. Rv3651 has a three-domain architecture that combines one cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA (GAF) domain and two Per-ARNT-Sim (PAS) domains. GAF and PAS domains are sensor domains that are typically linked to signaling effector molecules. Unlike these sensor-effector proteins, Rv3651 is an unusual sensor domain-only protein with highly divergent sequence. The structure suggests that Rv3651 integrates multiple different signals and serves as a scaffold to facilitate signal transfer.

PubMed: 29119630
DOI: 10.1002/pro.3343

実験手法

X-RAY DIFFRACTION (1.95 Å)