4Q6L

LpoB C-terminal domain from Salmonella enterica (Native)

4Q6L の概要

• エントリーDOI: 10.2210/pdb4q6l/pdb
• 関連するPDBエントリー: 4Q6V 4Q6Z
• 分子名称: Penicillin-binding protein activator LpoB (2 entities in total)
• 機能のキーワード: mixed alpha-beta, lipoprotein, activator of pbp1b, pbp1b, lipidation, outer-membrane, protein binding
• 由来する生物種: Salmonella enterica subsp. enterica serovar Typhimurium
• 細胞内の位置: Cell outer membrane; Lipid-anchor; Periplasmic side (By similarity): Q8ZQ08
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14360.16

構造登録者

King, D.T.,Strynadka, N.C.J. (登録日: 2014-04-22, 公開日: 2014-05-14, 最終更新日: 2024-02-28)

主引用文献

King, D.T.,Lameignere, E.,Strynadka, N.C.
Structural Insights into the Lipoprotein Outer Membrane Regulator of Penicillin-binding Protein 1B.
J.Biol.Chem., 289:19245-19253, 2014

PubMed Abstract: In bacteria, the synthesis of the protective peptidoglycan sacculus is a dynamic process that is tightly regulated at multiple levels. Recently, the lipoprotein co-factor LpoB has been found essential for the in vivo function of the major peptidoglycan synthase PBP1b in Enterobacteriaceae. Here, we reveal the crystal structures of Salmonella enterica and Escherichia coli LpoB. The LpoB protein can be modeled as a ball and tether, consisting of a disordered N-terminal region followed by a compact globular C-terminal domain. Taken together, our structural data allow us to propose new insights into LpoB-mediated regulation of peptidoglycan synthesis.

PubMed: 24808177
DOI: 10.1074/jbc.M114.565879

実験手法

X-RAY DIFFRACTION (2.2 Å)