4Q1Y

Mutations Outside the Active Site of HIV-1 Protease Alter Enzyme Structure and Dynamic Ensemble of the Active Site to Confer Drug Resistance

4Q1Y の概要

関連するPDBエントリー4Q1W 4Q1X
分子名称aspartyl protease, PHOSPHATE ION, ACETATE ION, ... (5 entities in total)
機能のキーワードhiv-1 protease, aids, inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Human immunodeficiency virus 1
ポリマー鎖数2
分子量合計22737.38
構造登録者
主引用文献
Ragland, D.A.,Nalivaika, E.A.,Nalam, M.N.,Prachanronarong, K.L.,Cao, H.,Bandaranayake, R.M.,Cai, Y.,Kurt-Yilmaz, N.,Schiffer, C.A.
Drug resistance conferred by mutations outside the active site through alterations in the dynamic and structural ensemble of HIV-1 protease.
J.Am.Chem.Soc., 136:11956-11963, 2014
PubMed: 25091085 (主引用文献が同じPDBエントリー)
DOI: 10.1021/ja504096m
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.5 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.208110.5%0.6%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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