4Q1N
Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors
Summary for 4Q1N
Entry DOI | 10.2210/pdb4q1n/pdb |
Related | 4PYV |
Descriptor | Renin, DIMETHYL SULFOXIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | aspartic protease, angiotensin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76255.07 |
Authors | Schiering, N.,D'Arcy, A.,Irie, O.,Yokokawa, F. (deposition date: 2014-04-04, release date: 2014-08-06, Last modification date: 2020-07-29) |
Primary citation | Ehara, T.,Irie, O.,Kosaka, T.,Kanazawa, T.,Breitenstein, W.,Grosche, P.,Ostermann, N.,Suzuki, M.,Kawakami, S.,Konishi, K.,Hitomi, Y.,Toyao, A.,Gunji, H.,Cumin, F.,Schiering, N.,Wagner, T.,Rigel, D.F.,Webb, R.L.,Maibaum, J.,Yokokawa, F. Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. ACS Med Chem Lett, 5:787-792, 2014 Cited by PubMed: 25050166DOI: 10.1021/ml500137b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report