4PYW
1.92 angstrom crystal structure of A1AT:TTAI ternary complex
Summary for 4PYW
Entry DOI | 10.2210/pdb4pyw/pdb |
Descriptor | Alpha-1-antitrypsin, ACE-THR-THR-ALA-ILE-NH2, GLYCEROL, ... (4 entities in total) |
Functional Keywords | serpin, hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 |
Total number of polymer chains | 3 |
Total formula weight | 46652.94 |
Authors | Nyon, M.P.,Day, J.,Gooptu, B. (deposition date: 2014-03-28, release date: 2015-06-10, Last modification date: 2022-08-24) |
Primary citation | Nyon, M.P.,Prentice, T.,Day, J.,Kirkpatrick, J.,Sivalingam, G.N.,Levy, G.,Haq, I.,Irving, J.A.,Lomas, D.A.,Christodoulou, J.,Gooptu, B.,Thalassinos, K. An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of alpha 1 -antitrypsin upon ligand binding. Protein Sci., 24:1301-1312, 2015 Cited by PubMed: 26011795DOI: 10.1002/pro.2706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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