4PY2

Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor 1-{3-[(3,5-DICHLOROBENZYL)AMINO]PROPYL}-3-THIOPHEN-3-YLUREA

4PY2 の概要

• エントリーDOI: 10.2210/pdb4py2/pdb
• 関連するPDBエントリー: 4DLP 4LNE 4PPW
• 分子名称: Methionine--tRNA ligase, 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: structural genomics, niaid, national institute of allergy and infectious diseases, seattle structural genomics center for infectious disease, ssgcid, ligase, methionyl-trna synthetase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Brucella melitensis
• 細胞内の位置: Cytoplasm : Q2YQ76
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 182522.63

構造登録者

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2014-03-25, 公開日: 2015-04-15, 最終更新日: 2023-09-20)

• 主引用文献: Ojo, K.K.,Ranade, R.M.,Zhang, Z.,Dranow, D.M.,Myers, J.B.,Choi, R.,Nakazawa Hewitt, S.,Edwards, T.E.,Davies, D.R.,Lorimer, D.,Boyle, S.M.,Barrett, L.K.,Buckner, F.S.,Fan, E.,Van Voorhis, W.C.; Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.; Plos One, 11:e0160350-e0160350, 2016; PubMed: 27500735; DOI: 10.1371/journal.pone.0160350

実験手法

X-RAY DIFFRACTION (2.15 Å)