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4PVT

Crystal Structure of VIM-2 metallo-beta-lactamase in complex with ML302F

Summary for 4PVT
Entry DOI10.2210/pdb4pvt/pdb
Related1KO2 1KO3 4PVO
DescriptorBeta-lactamase class B VIM-2, ZINC ION, (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, ... (6 entities in total)
Functional Keywordsalpha-beta/beta-alpha, beta-lactamase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourcePseudomonas aeruginosa
Total number of polymer chains2
Total formula weight52622.74
Authors
Aik, W.S.,Brem, J.,McDonough, M.A.,Schofield, C.J. (deposition date: 2014-03-18, release date: 2014-11-19, Last modification date: 2023-11-08)
Primary citationBrem, J.,van Berkel, S.S.,Aik, W.,Rydzik, A.M.,Avison, M.B.,Pettinati, I.,Umland, K.D.,Kawamura, A.,Spencer, J.,Claridge, T.D.,McDonough, M.A.,Schofield, C.J.
Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition.
Nat.Chem., 6:1084-1090, 2014
Cited by
PubMed: 25411887
DOI: 10.1038/nchem.2110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

数据于2024-03-27公开中

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