4PV7

Cocrystal structure of dipeptidyl-peptidase 4 with an indole scaffold inhibitor

4PV7 の概要

• エントリーDOI: 10.2210/pdb4pv7/pdb
• 分子名称: Dipeptidyl peptidase 4 soluble form, 1-[2-(2,4-dichlorophenyl)-1-(methylsulfonyl)-1H-indol-3-yl]methanamine (2 entities in total)
• 機能のキーワード: beta-propeller, hydrolase, extrocellular side, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Dipeptidyl peptidase 4 soluble form: Secreted. Cell membrane; Single-pass type II membrane protein: P27487
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 175329.77

構造登録者

Xiao, P.,Guo, R.,Huang, S.,Cui, H.,Ye, S.,Zhang, Z. (登録日: 2014-03-15, 公開日: 2015-03-18)

• 主引用文献: Xiao, P.,Guo, R.,Huang, S.,Cui, H.,Ye, S.,Zhang, Z.; Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold; Chin.Chem.Lett., 25:673-676, 2014; DOI: 10.1016/j.cclet.2014.03.047

実験手法

X-RAY DIFFRACTION (3.24 Å)