4PP7

Highly Potent and Selective 3-N-methylquinazoline-4(3H)-one Based Inhibitors of B-RafV600E Kinase

4PP7 の概要

• エントリーDOI: 10.2210/pdb4pp7/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, N-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide (2 entities in total)
• 機能のキーワード: serine/threonine-protein kinase b-raf, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): P15056
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71280.16

構造登録者

Wenglowsky, S.,Ren, L.,Grina, J.,Hansen, J.D.,Laird, E.R.,Moreno, D.,Dinkel, V.,Gloor, S.L.,Hastings, G.,Rana, S.,Rasor, K.,Sturgis, H.L.,Voegtli, W.C.,Vigers, G.P.A.,Willis, B.,Mathieu, S.,Rudolph, J. (登録日: 2014-02-26, 公開日: 2014-04-09, 最終更新日: 2024-02-28)

• 主引用文献: Wenglowsky, S.,Ren, L.,Grina, J.,Hansen, J.D.,Laird, E.R.,Moreno, D.,Dinkel, V.,Gloor, S.L.,Hastings, G.,Rana, S.,Rasor, K.,Sturgis, H.L.,Voegtli, W.C.,Vigers, G.,Willis, B.,Mathieu, S.,Rudolph, J.; Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase.; Bioorg.Med.Chem.Lett., 24:1923-1927, 2014; PubMed: 24675381; DOI: 10.1016/j.bmcl.2014.03.007

実験手法

X-RAY DIFFRACTION (3.4 Å)