4PJV

Structure of PARP2 catalytic domain bound to inhibitor BMN 673

Summary for 4PJV

• Entry DOI: 10.2210/pdb4pjv/pdb
• Related: 4PJT
• Descriptor: Poly [ADP-ribose] polymerase 2, (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, GLYCEROL, ... (4 entities in total)
• Functional Keywords: parp2, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q9UGN5
• Total number of polymer chains: 2
• Total formula weight: 84692.83

Authors

Aoyagi-Scharber, M.,Gardberg, A.S.,Edwards, T.L. (deposition date: 2014-05-12, release date: 2014-09-24, Last modification date: 2023-09-27)

• Primary citation: Aoyagi-Scharber, M.,Gardberg, A.S.,Yip, B.K.,Wang, B.,Shen, Y.,Fitzpatrick, P.A.; Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone.; Acta Crystallogr.,Sect.F, 70:1143-1149, 2014; PubMed: 25195882; DOI: 10.1107/S2053230X14015088

Experimental method

X-RAY DIFFRACTION (2.5 Å)