4PDW

A benzonitrile analogue inhibits rhinovirus replication

Summary for 4PDW

• Entry DOI: 10.2210/pdb4pdw/pdb
• Descriptor: Genome polyprotein, Capsid protein VP4/VP2, GLYCEROL, ... (7 entities in total)
• Functional Keywords: benzonitrile inhibitor, virus
• Biological source: Human rhinovirus 14 (HRV-14); More
• Cellular location: Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03303 P03303 P03303
• Total number of polymer chains: 4
• Total formula weight: 95177.21

Authors

Querol-Audi, J.,Guerra, P.,Lacroix, C.,Roche, M.,Franco, D.,Froeyen, M.,Terme, T.,Vanelle, P.,Neyts, J.,Leyssen, P.,Verdaguer, N. (deposition date: 2014-04-22, release date: 2014-07-02, Last modification date: 2023-12-20)

• Primary citation: Lacroix, C.,Querol-Audi, J.,Roche, M.,Franco, D.,Froeyen, M.,Guerra, P.,Terme, T.,Vanelle, P.,Verdaguer, N.,Neyts, J.,Leyssen, P.; A novel benzonitrile analogue inhibits rhinovirus replication.; J.Antimicrob.Chemother., 69:2723-2732, 2014; PubMed: 24948704; DOI: 10.1093/jac/dku200

Experimental method

X-RAY DIFFRACTION (3 Å)