4PDW

A benzonitrile analogue inhibits rhinovirus replication

4PDW の概要

• エントリーDOI: 10.2210/pdb4pdw/pdb
• 分子名称: Genome polyprotein, Capsid protein VP4/VP2, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: benzonitrile inhibitor, virus
• 由来する生物種: Human rhinovirus 14 (HRV-14); 詳細
• 細胞内の位置: Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P03303 P03303 P03303
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95177.21

構造登録者

Querol-Audi, J.,Guerra, P.,Lacroix, C.,Roche, M.,Franco, D.,Froeyen, M.,Terme, T.,Vanelle, P.,Neyts, J.,Leyssen, P.,Verdaguer, N. (登録日: 2014-04-22, 公開日: 2014-07-02, 最終更新日: 2023-12-20)

主引用文献

Lacroix, C.,Querol-Audi, J.,Roche, M.,Franco, D.,Froeyen, M.,Guerra, P.,Terme, T.,Vanelle, P.,Verdaguer, N.,Neyts, J.,Leyssen, P.
A novel benzonitrile analogue inhibits rhinovirus replication.
J.Antimicrob.Chemother., 69:2723-2732, 2014

PubMed Abstract: To study the characteristics and the mode of action of the anti-rhinovirus compound 4-[1-hydroxy-2-(4,5-dimethoxy-2-nitrophenyl)ethyl]benzonitrile (LPCRW_0005).

PubMed: 24948704
DOI: 10.1093/jac/dku200

実験手法

X-RAY DIFFRACTION (3 Å)