4PCI
Crystal Structure of the first bromodomain of BRD4 in complex with B16
Summary for 4PCI
Entry DOI | 10.2210/pdb4pci/pdb |
Related | 4PCE |
Descriptor | Bromodomain-containing protein 4, (4S)-1-methyl-4-phenyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15413.76 |
Authors | Dong, J.,Caflisch, A. (deposition date: 2014-04-15, release date: 2014-05-14, Last modification date: 2023-09-27) |
Primary citation | Zhao, H.,Gartenmann, L.,Dong, J.,Spiliotopoulos, D.,Caflisch, A. Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking. Bioorg.Med.Chem.Lett., 24:2493-2496, 2014 Cited by PubMed: 24767840DOI: 10.1016/j.bmcl.2014.04.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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