4PBX

Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma

Summary for 4PBX

Entry DOI	10.2210/pdb4pbx/pdb
Related	2YD2 2YD3 2YD9
Descriptor	Receptor-type tyrosine-protein phosphatase S, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	signaling protein, synapse cell signalling cell surface receptor, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : Q13332
Total number of polymer chains	1
Total formula weight	64786.45
Authors	Coles, C.H.,Mitakidis, N.,Zhang, P.,Elegheert, J.,Lu, W.,Stoker, A.W.,Nakagawa, T.,Craig, A.M.,Jones, E.Y.,Aricescu, A.R. (deposition date: 2014-04-14, release date: 2014-11-12, Last modification date: 2023-12-20)
Primary citation	Coles, C.H.,Mitakidis, N.,Zhang, P.,Elegheert, J.,Lu, W.,Stoker, A.W.,Nakagawa, T.,Craig, A.M.,Jones, E.Y.,Aricescu, A.R. Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis. Nat Commun, 5:5209-5209, 2014 Cited by PubMed: 25385546 DOI: 10.1038/ncomms6209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation