4PAY

Crystal structure of an N-terminal fragment of the Legionella pneumophila effector protein SidC.

「4OM6」から置き換えられました

4PAY の概要

• エントリーDOI: 10.2210/pdb4pay/pdb
• 分子名称: SidC, interaptin, BARIUM ION (3 entities in total)
• 機能のキーワード: tethering, vesicular transport, legionella pneumophila effector, transport protein
• 由来する生物種: Legionella pneumophila subsp. pneumophila
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141450.66

構造登録者

Horenkamp, F.A.,Mukherjee, S.,Alix, E.,Schauder, C.M.,Hubber, A.M.,Roy, C.R.,Reinisch, K.M. (登録日: 2014-04-10, 公開日: 2014-06-25, 最終更新日: 2024-11-13)

主引用文献

Horenkamp, F.A.,Mukherjee, S.,Alix, E.,Schauder, C.M.,Hubber, A.M.,Roy, C.R.,Reinisch, K.M.
Legionella pneumophila Subversion of Host Vesicular Transport by SidC Effector Proteins.
Traffic, 15:488-499, 2014

PubMed Abstract: Tethering proteins play a key role in vesicular transport, ensuring that cargo arrives at a specific destination. The bacterial effector protein SidC and its paralog SdcA have been described as tethering factors encoded by the intracellular pathogen Legionella pneumophila. Here, we demonstrate that SidC proteins are important for early events unique to maturation of vacuoles containing Legionella and discover monoubiquitination of Rab1 as a new SidC-dependent activity. The crystal structure of the SidC N-terminus revealed a novel fold that is important for function and could be involved in Legionella adaptations to evolutionarily divergent host cells it encounters in natural environments.

PubMed: 24483784
DOI: 10.1111/tra.12158

実験手法

X-RAY DIFFRACTION (2.77 Å)