4P8O
S. aureus gyrase bound to an aminobenzimidazole urea inhibitor
Summary for 4P8O
Entry DOI | 10.2210/pdb4p8o/pdb |
Descriptor | DNA gyrase subunit B, 1-ethyl-3-[5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzimidazol-2-yl]urea (3 entities in total) |
Functional Keywords | antibacterial, gram-positive, gyrase, topoisomerase, staphylococcus aureus, isomerase |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm : Q6GKU0 |
Total number of polymer chains | 2 |
Total formula weight | 43644.65 |
Authors | Jacobs, M.D. (deposition date: 2014-03-31, release date: 2014-10-29, Last modification date: 2023-12-27) |
Primary citation | Grillot, A.L.,Tiran, A.L.,Shannon, D.,Krueger, E.,Liao, Y.,O'Dowd, H.,Tang, Q.,Ronkin, S.,Wang, T.,Waal, N.,Li, P.,Lauffer, D.,Sizensky, E.,Tanoury, J.,Perola, E.,Grossman, T.H.,Doyle, T.,Hanzelka, B.,Jones, S.,Dixit, V.,Ewing, N.,Liao, S.,Boucher, B.,Jacobs, M.,Bennani, Y.,Charifson, P.S. Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability. J.Med.Chem., 57:8792-8816, 2014 Cited by PubMed: 25317480DOI: 10.1021/jm500563g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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