4P72

PheRS in complex with compound 2a

Summary for 4P72

• Entry DOI: 10.2210/pdb4p72/pdb
• Related: 4P71 4P73 4P74 4P75
• Descriptor: Phenylalanine--tRNA ligase beta subunit, Phenylalanine--tRNA ligase alpha subunit, 2-{3-[(4-chloropyridin-2-yl)amino]phenoxy}-N-methylacetamide, ... (4 entities in total)
• Functional Keywords: phenylalanine trna synthetase, phers, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Pseudomonas aeruginosa; More
• Cellular location: Cytoplasm : Q9I0A4 Q9I0A3
• Total number of polymer chains: 4
• Total formula weight: 250610.94

Authors

Ferguson, A.D. (deposition date: 2014-03-25, release date: 2014-06-25, Last modification date: 2023-09-27)

• Primary citation: Abibi, A.,Ferguson, A.D.,Fleming, P.R.,Gao, N.,Hajec, L.I.,Hu, J.,Laganas, V.A.,McKinney, D.C.,McLeod, S.M.,Prince, D.B.,Shapiro, A.B.,Buurman, E.T.; The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.; J.Biol.Chem., 289:21651-21662, 2014; PubMed: 24936059; DOI: 10.1074/jbc.M114.574061

Experimental method

X-RAY DIFFRACTION (2.62 Å)