4P45

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor JRB-4-73

4P45 の概要

• エントリーDOI: 10.2210/pdb4p45/pdb
• 分子名称: Glutamate carboxypeptidase 2, N-(4-fluorobenzoyl)-L-valyl-O-[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]-L-serine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: glutamate carboxypeptidase ii (gcpii), naaladase, prostate-specific membrane antigen, phosphoramidate, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83699.64

構造登録者

Novakova, Z.,Barinka, C. (登録日: 2014-03-11, 公開日: 2015-05-20, 最終更新日: 2020-07-29)

• 主引用文献: Novakova, Z.,Cerny, J.,Choy, C.J.,Nedrow, J.R.,Choi, J.K.,Lubkowski, J.,Berkman, C.E.,Barinka, C.; Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities.; Febs J., 283:130-143, 2016; PubMed: 26460595; DOI: 10.1111/febs.13557

実験手法

X-RAY DIFFRACTION (1.87 Å)