4OVU

Crystal Structure of p110alpha in complex with niSH2 of p85alpha

4OVU の概要

• エントリーDOI: 10.2210/pdb4ovu/pdb
• 関連するPDBエントリー: 4OVV
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha (3 entities in total)
• 機能のキーワード: p110, p85, pi3kca, pi3k, pik3r1, phosphatidilynositol 3, 4, 5 triphosphate, pip2, phosphatidylinositol 4, 5 bisphosphate, lipid kinase, phosphoinositide, 3-kinase, signaling, phosphatidylinositol 3-kinase, transferase-transferase regulator complex, transferase/transferase regulator
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 161489.54

構造登録者

Gabelli, S.B.,Vogelstein, B.,Miller, M.S.,Amzel, L.M. (登録日: 2014-01-14, 公開日: 2014-09-03, 最終更新日: 2023-09-27)

• 主引用文献: Miller, M.S.,Schmidt-Kittler, O.,Bolduc, D.M.,Brower, E.T.,Chaves-Moreira, D.,Allaire, M.,Kinzler, K.W.,Jennings, I.G.,Thompson, P.E.,Cole, P.A.,Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.; Structural basis of nSH2 regulation and lipid binding in PI3K alpha.; Oncotarget, 5:5198-5208, 2014; PubMed: 25105564

実験手法

X-RAY DIFFRACTION (2.96 Å)