4OVE

X-ray Crystal Structure of Mouse Netrin-1

4OVE の概要

• エントリーDOI: 10.2210/pdb4ove/pdb
• 分子名称: Netrin-1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: similar to laminin gamma-1, domain vi: beta-sandwich jelly-roll, domains v-1, v-2, v-3: laminin-type epidermal growth factor, structural calcium, axon guidance cue, survival factor, neogenin, dcc, unc5a, unc5b, unc5c, unc5d, dscam, extracellular matrix, apoptosis
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50626.25

構造登録者

Meier, M.,Nikodemus, D.,Reuten, R.,Patel, T.R.,Orriss, G.,Okun, N.,Koch, M.,Stetefeld, J. (登録日: 2014-02-21, 公開日: 2015-02-25, 最終更新日: 2020-07-29)

• 主引用文献: Grandin, M.,Meier, M.,Delcros, J.G.,Nikodemus, D.,Reuten, R.,Patel, T.R.,Goldschneider, D.,Orriss, G.,Krahn, N.,Boussouar, A.,Abes, R.,Dean, Y.,Neves, D.,Bernet, A.,Depil, S.,Schneiders, F.,Poole, K.,Dante, R.,Koch, M.,Mehlen, P.,Stetefeld, J.; Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers.; Cancer Cell, 29:173-185, 2016; PubMed: 26859457; DOI: 10.1016/j.ccell.2016.01.001

実験手法

X-RAY DIFFRACTION (2.64 Å)