4OTJ

The complex of murine cyclooxygenase-2 with a conjugate of indomefathin and podophyllotoxin, N-{(succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide

Summary for 4OTJ

Entry DOI	10.2210/pdb4otj/pdb
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	oxidoreductase, nsaids, glycosylation, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	4
Total formula weight	279546.35
Authors	Xu, S.,Uddin, M.J.,Banerjee, S.,Marnett, L.J. (deposition date: 2014-02-13, release date: 2015-04-08, Last modification date: 2023-09-20)
Primary citation	Uddin, M.J.,Crews, B.C.,Xu, S.,Ghebreselasie, K.,Daniel, C.K.,Kingsley, P.J.,Banerjee, S.,Marnett, L.J. Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors. Acs Chem.Biol., 11:3052-3060, 2016 Cited by PubMed: 27588346 DOI: 10.1021/acschembio.6b00560 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation