4OTJ

The complex of murine cyclooxygenase-2 with a conjugate of indomefathin and podophyllotoxin, N-{(succinylpodophyllotoxinyl)but-4-yl}-2-{1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl}acetamide

4OTJ の概要

• エントリーDOI: 10.2210/pdb4otj/pdb
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nsaids, glycosylation, membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Mus musculus (mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 279546.35

構造登録者

Xu, S.,Uddin, M.J.,Banerjee, S.,Marnett, L.J. (登録日: 2014-02-13, 公開日: 2015-04-08, 最終更新日: 2023-09-20)

• 主引用文献: Uddin, M.J.,Crews, B.C.,Xu, S.,Ghebreselasie, K.,Daniel, C.K.,Kingsley, P.J.,Banerjee, S.,Marnett, L.J.; Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.; Acs Chem.Biol., 11:3052-3060, 2016; PubMed: 27588346; DOI: 10.1021/acschembio.6b00560

実験手法

X-RAY DIFFRACTION (2.11 Å)