4OQR
Structure of a CYP105AS1 mutant in complex with compactin
Summary for 4OQR
Entry DOI | 10.2210/pdb4oqr/pdb |
Related | 4OQS |
Descriptor | CYP105AS1, PROTOPORPHYRIN IX CONTAINING FE, Mevastatin, Compactin, ... (4 entities in total) |
Functional Keywords | cytochrome p450, monooxygenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Amycolatopsis orientalis |
Total number of polymer chains | 1 |
Total formula weight | 51635.78 |
Authors | Leys, D. (deposition date: 2014-02-10, release date: 2015-02-18, Last modification date: 2024-04-03) |
Primary citation | McLean, K.J.,Hans, M.,Meijrink, B.,van Scheppingen, W.B.,Vollebregt, A.,Tee, K.L.,van der Laan, J.M.,Leys, D.,Munro, A.W.,van den Berg, M.A. Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc.Natl.Acad.Sci.USA, 112:2847-2852, 2015 Cited by PubMed: 25691737DOI: 10.1073/pnas.1419028112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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