4OM7

Crystal structure of TIR domain of TLR6

4OM7 の概要

• エントリーDOI: 10.2210/pdb4om7/pdb
• 分子名称: Toll-like receptor 6 (2 entities in total)
• 機能のキーワード: tir fold, protein interaction, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : Q9Y2C9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42420.59

構造登録者

Park, H.H.,Jang, T.H. (登録日: 2014-01-26, 公開日: 2014-08-06, 最終更新日: 2024-11-27)

主引用文献

Jang, T.H.,Park, H.H.
Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR-TIR Interaction for Toll-Like Receptor Signaling Pathway.
J.Mol.Biol., 426:3305-3313, 2014

PubMed Abstract: Toll-like receptors (TLRs) are responsible for recognition of particular pathogens during the innate immune response and cytoplasmic Toll/interleukin-1 receptor (TIR) domain responsible for downstream signaling. TLR6 working with TLR2 can detect bacterial lipoprotein leading signal for nuclear factor-kappaB activation for immune response. To better understand TLR-mediated signaling event in the innate immune system, in this study, we report the first crystal structure of the TIR domain of TLR6 at 2.2Å resolution. Our structure reveals novel homo-dimerization interfaces, which might be a critical for the interaction with TIR-containing adaptor proteins and itself. We also report structural similarities and differences of TLR6 with those of other TIR domains, which may be functionally relevant.

PubMed: 25088687
DOI: 10.1016/j.jmb.2014.07.024

実験手法

X-RAY DIFFRACTION (2.204 Å)