4OK6
Crystal Structure of Hepatitis C Virus NS3 Helicase Inhibitor Co-complex with Compound 13 [[1-(2-methoxy-5-nitrobenzyl)-1H-indol-3-yl]acetic acid]
Summary for 4OK6
Entry DOI | 10.2210/pdb4ok6/pdb |
Related | 4OJQ 4OK3 4OK5 4OKS |
Descriptor | Serine protease NS3, CALCIUM ION, [1-(2-methoxy-5-nitrobenzyl)-1H-indol-3-yl]acetic acid, ... (4 entities in total) |
Functional Keywords | hepatitis, atpase, ntpase, ns3 helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Hepatitis C Virus |
Total number of polymer chains | 2 |
Total formula weight | 99981.25 |
Authors | Padyana, A.K. (deposition date: 2014-01-21, release date: 2014-03-05, Last modification date: 2024-02-28) |
Primary citation | Laplante, S.R.,Padyana, A.K.,Abeywardane, A.,Bonneau, P.,Cartier, M.,Coulombe, R.,Jakalian, A.,Wildeson-Jones, J.,Li, X.,Liang, S.,McKercher, G.,White, P.,Zhang, Q.,Taylor, S.J. Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus. J.Med.Chem., 57:2074-2090, 2014 Cited by PubMed: 24467709DOI: 10.1021/jm401432c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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