4OK5

Crystal Structure of Hepatitis C Virus NS3 Helicase Inhibitor Co-complex with Compound 9 [1-(3-ethynylbenzyl)-1H-indol-3-yl]acetic acid]

Summary for 4OK5

Entry DOI	10.2210/pdb4ok5/pdb
Related	4OJQ 4OK3 4OK6 4OKS
Descriptor	Serine protease NS3, CALCIUM ION, [1-(3-ethynylbenzyl)-1H-indol-3-yl]acetic acid, ... (4 entities in total)
Functional Keywords	hepatitis, atpase, ntpase, ns3 helicase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Hepatitis C Virus
Total number of polymer chains	2
Total formula weight	99930.25
Authors	Padyana, A.K. (deposition date: 2014-01-21, release date: 2014-03-05, Last modification date: 2024-02-28)
Primary citation	Laplante, S.R.,Padyana, A.K.,Abeywardane, A.,Bonneau, P.,Cartier, M.,Coulombe, R.,Jakalian, A.,Wildeson-Jones, J.,Li, X.,Liang, S.,McKercher, G.,White, P.,Zhang, Q.,Taylor, S.J. Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus. J.Med.Chem., 57:2074-2090, 2014 Cited by PubMed: 24467709 DOI: 10.1021/jm401432c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation