4OFB
Crystal structure of human BRCA1 BRCT in complex with nonphosphopeptide inhibitor
Summary for 4OFB
| Entry DOI | 10.2210/pdb4ofb/pdb |
| Descriptor | Breast cancer type 1 susceptibility protein, nonphosphopeptide inhibitor (2 entities in total) |
| Functional Keywords | brct domain, dsb dna damage repair, non-phosphorylated peptide, protein binding |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398 |
| Total number of polymer chains | 2 |
| Total formula weight | 26185.02 |
| Authors | Sun, L.,Edwards, R.A.,Glover, J.N.M. (deposition date: 2014-01-14, release date: 2015-04-15, Last modification date: 2017-11-22) |
| Primary citation | White, E.R.,Sun, L.,Ma, Z.,Beckta, J.M.,Danzig, B.A.,Hacker, D.E.,Huie, M.,Williams, D.C.,Edwards, R.A.,Valerie, K.,Glover, J.N.,Hartman, M.C. Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain. Acs Chem.Biol., 10:1198-1208, 2015 Cited by PubMed: 25654734DOI: 10.1021/cb500757u PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
Download full validation report
